Fractions and isolated compounds from Oxyanthus speciosus subsp. stenocarpus (Rubiaceae) have promising antimycobacterial and intracellular activity
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منابع مشابه
Determination of the Antimycobacterial Activity of the Fractions and Isolated Compounds from the Roots of Galenia Africana L. Var. Africana
The escalation of infections caused by M. tuberculosis, particularly those caused by MDR-TB strains is of considerable global concern. Since no new antituberculosis drugs have become available during the last forty years, there is obvious need for new and effective anti-tubercular drugs. There are reports of phytochemical analysis of essential oils, glycolipids, sesquiterpenoids, triterpenoids ...
متن کاملAntidermatophytic and Toxicological Evaluations of Dichloromethane-Methanol Extract, Fractions and Compounds Isolated from Coula edulis
Background: Coula edulis Bail (Olacaceae), is an evergreen tree growing to a height of 25-38 m. This study aimed at evaluating the antidermatophytic and toxicological properties of the stem bark of C. edulis extract as well as fractions and compounds isolated from it. Methods: The plant extract was prepared by maceration in CH2Cl2-MeOH (1:1 v/v). The fractionation of this extract was do...
متن کاملTriterpenes and the Antimycobacterial Activity of Duroia macrophylla Huber (Rubiaceae)
Duroia macrophylla popularly known as "cabeça-de-urubú," "apuruí," or "puruí-grande-da-mata" occurs in the Amazon Forest. Its leaves and branches were collected twice and extracted with dichloromethane and methanol. All extracts were subjected to phytochemical investigation and terpenes and flavonoids were found in all dichloromethane and methanol extracts, respectively. Methanol extracts from ...
متن کاملSome South African Rubiaceae Tree Leaf Extracts Have Antimycobacterial Activity Against Pathogenic and Non-pathogenic Mycobacterium Species.
Tuberculosis (TB) caused by Mycobacterium tuberculosis remains an ongoing threat to human health. Many plant species contain antimycobacterial compounds, which may serve as template molecules for new anti-TB drugs. The Rubiaceae family is the largest family of trees in southern Africa, and preliminary evidence revealed antimycobacterial activity in several species of the genus, motivating furth...
متن کاملAntimycobacterial Activity of Isolated Compounds from Lippia Javanica and Hoslundia Opposita
Eight compounds isolated from Lippia javanica and three compounds, from Hoslundia opposita were tested against Mycobacterium tuberculosis at concentrations of 200, 100, 50 and 25μg/ml. Compound “6-Methoxyluteolin 4'-methyl ether” isolated from L. javanica exhibited a minimum inhibitory concentration (MIC) of 200 μg/ml against M. tuberculosis. Of all the compounds tested against a drug-sensitive...
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ژورنال
عنوان ژورنال: BMC Complementary and Alternative Medicine
سال: 2019
ISSN: 1472-6882
DOI: 10.1186/s12906-019-2520-x